My Nomad came with a regular QR skewer through the Rohloff axle. I replaced it with a pitlock, which hasn't given me any problems.
It is an interesting point though, that the skewer gets twisted when I tighten up the pitlock nut. That would definitely not be fun, to have a failure there! I don't apply a whole lot of torque. My pitlock key is on a keyring, along with my Kryponite U-lock key. I just use that key ring for leverage. I typically remove the wheels twice a year - switching to studded tires at the start of winter and back to smooth tires at the end.
I usually lock the rear wheel anyway so what's the point of the pitlock? But then sometimes a situation makes locking difficult so I end up... the other day I just locked the front wheel to a post so it was my pitlocks that held the rest together... except with the S&S (de)couplers... well how hard would it be to hacksaw through frame tubes, anyway?