My 4 bikes have either Slime inner tubes or injected Slime and so far I have to say no problems.
Maybe I've been lucky never having had to put it to the test.
Many years ago when I sold my son's mountain bike the new owner called to ask what the green discs he had found on the inner tubes were. All my son ever did was pump up the tyres when they were going soft and see if anything was sticking out of the tyres.