When touring, I use skewers that use a 5mm allen wrench, not one that use a special key. And for riding near home (not touring) I use that type of skewer on my dynohub wheels but quick release on my other wheels. And to avert problems later, I carry a spare 5mm allen wrench with my spare inner tubes.
I do this solely because I suspect that most thieves are opportunists, do not carry around an allen wrench or multitool in their pocket. Thus, I do not want them to steal a wheel.
Never had a problem with a wheel coming out.
All my other wheels use a conventional quick release.
That said, my only disc brake is on the rear on my titanium bike, the front brake on that bike is a rim brake. The disc brake unit is on the chainstay, not seat stay, thus any forces on the axle from braking would only push the axle further into the dropouts, not out.
I had problems half a century ago with rear wheels slipping in the horizontal dropouts on the drive side if I was pedaling hard on a bike with nutted axles, that was from not tightening it enough and the chain tension could pull the wheel forward on the drive side. If you are many miles from home and your axle slips in the dropout far enough that the tire rubs on the chainstay and you do not have a wrench with you, you remember that problem for a long time. So, yes, I remember that happening a few times.