The Thorn chainring is very long-lasting. The Rohloff sprocket is very long-lasting but often on a different time-schedule than the chainring. A common replacement for the Thorn chainring is the Surly stainless steel chainring -- you guessed it -- which lasts forever. So the likelihood is that someone going to 50x21 might have to throw out part-worn components. In addition, the Chainglider is pretty popular among members of the forum, and that only works with particular tooth counts in both the sprocket and the chainring, and it is virtually indestructable. Furthermore, you might consider that a large chainring on a touring bike makes your transmission more vulnerable to damage when you go off the tarmac -- or even ride through a pothole on the tarmac.