You can run a Rohloff chain until it falls off and you have run out of adjustment on the EBB. However, you need to make a judgement of when to change in relation to wear of the sprocket and chainwheel. For me this is about 5000 miles when I also reverse the sprocket and chain wheel. Another strategy is to rotate two chains every 2-3000 miles so they both wear evenly with the sprocket. I start again each 10,000 miles (new sprocket, chain, probably chainring) but others have got double that.