I operate hefty 25mm wide Exal rims, heavy Sapim spokes, and very heavy 60mm Big Apple tyres on substantial hubs (Rohloff rear, electric front). My experience is that after the initial breakaway from a standing start, which these days I achieve in top with just a touch of the motor, the bike picks up speed deceptively fast on the pedals in 11th gear without the cyclist breaking into a sweat. The spacing of the Rohloff gears and the ease of changing gears are factors, of course. Once going the thing has a momentum of its own that can catch out the unwary cyclist who begs a ride on my bike in tight corners where such a long wheelbase bike must be turned in early, and the deceptive speed, and reluctance to shed it merely for stopping pedaling, aggravates the effect. (It's like putting a guy used to a small hatchback into six litres of Mercedes.) Roadies especially, who never fail to comment on how heavy my bike is, are caught out time and again by this momentum in a bike they expect to be slower than their carbon confection. And it's all in the wheels, because the frame itself is built of specially developed very thin wall Columbus steel that is, surprisingly, lighter than my two aluminium similar purpose (Dutch stadssportief) bikes' frames. So, I conclude that weight low down in the wheels has a positive effect.