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I ordered my Mercury with 50mm G-Ones and Thorn supplied them tubeless with no recommendation for tubes. I've only had to make one repair on the road, and as it was a front tyre I coukd see it was holed by the sealant spraying gently from the tread. Easy therefore to find the hole, and with enough air pressure still in the tyre that it was easily plugged. My guess is that 700c x 40 would have enough volume to work this way also.
By way of contrast, I left the rear tyre sealant unreplenished for six months or so and one day picked up a small puncture that didn't make itself obvious on the road and yet didn't quite seal. The tyre deflated fully overnight in my garage, and I could not remount it with a garage-style hand pump. I added some sealant and took the wheel to my local bike shop, which mounted the tyre with a compressor. I'd taken plugs with me, expecting that leaking sealant would reveal the site of the hole. But the fresh sealant had immediately sealed the leak, and that tyre ran unplugged for several more months until tread wear led me to change it.
That is exactly why I doubt I will ever go to tubeless. You need to maintain your sealant. How often, that is something that I do not know but I have heard at least once a year. I live in a part of the world that most people only bike about six months of the year, so once a year might mean six months. (It snowed here yesterday, most people put their bikes away for winter weeks ago.)
I average one puncture a year. And I always carry a spare tube on each bike, a puncture is not a big problem for me. And in an average year I ride five or six or seven different bikes, thus maintaining sealant in that many bikes would take a lot more time for me than dealing with an annual puncture.
And one bike is shod with studded tires in winter, regular tires in summer, thus two tire changes each year on two wheels.
Even if I only put sealant in the three bikes that I ride most, that is still maintaining sealant in six wheels which is a lot more time consuming that dealing with one annual (on average) puncture.
For those that get a lot of punctures and do not have many wheels to deal with sealant maintenance, tubeless might be great, but it is not for me.