It's one of the reasons I no longer have an Audax bike, even on mucky winter roads, 28mm tyres and deep drop calipers left too little clearance to keep them clear.
One thing to consider is what's causing the blockage, I find the less clutter and fittings on the inside of the guard the better. Once you've picked something up, you want it to make it's way round as easily as possible, or it just builds up. The SKS brackets are pretty poor in this regard, I used to move them from under to over the guard. The direct fitting on Thorn bikes also benefits from a low profile button head (At the risk of making it harder to remove in several years time) You can also control to some extent where the blockage occurs, the brackets holding my mudflaps are the first thing to clog, that was accidental, but a happy accident I'll repeat, it's an easy place to clear.
I'm not familiar with the guards you mention, or with what's currently available, the designs change so frequently. I've had the Bluemels Matt 45mm on both Mercurys, Over 35mm Supremes on the first and 40mm Supremes or Almotions on the MkIII, they're not perfect, but better than the standard SKS Cromoplastics. On another bike I have the SKS Edge Al. these have a different profile with a flatter top and deep edge, I have them if the 56mm size, the 46's should fit a Mercury, but I haven't tried. On the bike I have them there's no shortage of space, but I think on a bike where it was tight, they'd maximise the clearance.