I did a trip where there were a lot of thorns (the pointed type, not the wheeled type), fitted a suspension front fork to my Nomad Mk II and pretended it was a mountain bike. We were doing day trips, not touring.
Lots of thorns in the area. I had a tube failure, but it was a tube defect. Otherwise no problems. But, can't say if I would have had any problems if I did not use slime in my tubes first.
Slime is water based, you can use water to clean it off, which is one reason I chose that, I could add it through a presta valve with a removable core, and then clean out the valve seat, and replace the core.
Later, adding air, I was careful to avoid having air in the tube come out when I took the pump chuck off the valve, as I did not want sealant blowback.
That is the only time I used it. I still have a bottle of it and if I was to go there again, I might use it again.
I have heard that if you have sealant on a tube, that putting a patch on the tube can be problematic. Have heard that in a generic way, I do not know if that includes Slime or not, as I would assume if you had a tube that you washed off the sealant, dried it, that a patch would stick. Have not tried it, but it is something to be aware of. I would be inclined to use a bit of rubbing alcohol to wipe off the area to be patched and let that dry first.
Regarding sealant, there are several different sealants that people use for tubeless tires, but the only sealant I have bought is Slime. Slime sealant for tubes is different than their sealant for tubeless tires, I do not know what the difference is.